Manuscripts are the treasure of Knowledge in history and culture of a nation The Bangladesh National Museum has 1650 manuscripts (Sanskrit and Berlin) in its collection. This catalogue accumulated a selection of 500 ancient manuscripts, which is divided in two volumes. This is the 1st volume contains 250 Sanskrit and Bengali manuscripts. The Sanskrit manuscripts are of kavya (poem), drama, grammar, lexicon, purana, jyotisa, tantra, smrti, Ramayana and Mahabharata, etc. while the Bengali manuscripts are of mainly poem and Islam. The major authors of Sanskrit manuscripts identified are Valmiki, Vyasadeva, Amarasimha Rupagosvami, Kavikarnapura, Jimutavahana, Raghunandana while that of the Bengali manuscripts identified are Krttivasa Kaxirama Dasa, Krsnadasa Kaviraja, Alaol, Abdul Hakim, Fakir Garibullah and so on. Most of the Islamic books are printed those were printed in 19th and early 20th century AD. To preserve the exact pronunciation of the Sanskrit and Bengali words the diacritical marks have been used in translation. The writing materials of the manuscripts are tulat paper, palm leaf and mill paper. Most of the manuscripts are written on tulat paper. A good number of the manuscripts identified were copied between the later part of the 17th century and the middle part of the 18th century AD. The later manuscripts are in better condition.